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1. A dose calibrator is used to measure the activities of dosages of radiopharmaceuticals to be administered to patients.
2. The calibrator cannot directly measure activity. Instead, it measures the intensity of the radiation emitted by a dosage of a radiopharmaceutical.
3. The manufacturer of a dose calibrator determines calibration factors relating the magnitude of the signal from the detector to activity for specific radionuclides commonly used in nuclear medicine.
4. The calibration factor takes in to account the number, type and energy of the emissions per decay as well as considerations for the effects of Pb shielding and well geometry.
5. High pressure gas (22 atmos) within the calibrator leads to greater density, increasing the intrinsic efficiency of the detector.

Designed features:
6. Maximise geometric efficiency.
7. Minimise variation due to small differences in source position.
8. Wall, source volume and source-holder thickness lead to problems with pure beta emitters.


1. Bushberg, J. T. (2012). The essential physics of medical imaging. Philadelphia: Wolters Kluwer Health/Lippincott Williams & Wilkins. Find it at Amazon
2. Heggie, J. C., Liddell, N. A., & Maher, K. P. (1997). Applied imaging technology. Melbourne: St. Vincents Hospital.

Ⓒ A. Manickam 2018

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