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RADIOPHARMACEUTICALS-MECHANISMS OF LOCALIZATION, PT 2

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RADIOPHARMACEUTICALS-MECHANISMS OF LOCALIZATION, PT 2

6. Capillary blockade - assessment of pulmonary perfusion by the injection of Tc-99m-MAA, which is trapped in the pulmonary capillary bed.

7. Perfusion - the perfusion phase of a three-phase bone scan helps to distinguish between an acute process (e.g., osteomyelitis) and remote fracture.

8. Chemotaxis - 111 In and 99 Tc m -labeled leukocytes respond to products formed in immunologic reactions.

9. Antibody-antigen complexation - an in vitro test called radioimmunoassay (RIA) makes use of the competition between a radiolabeled antigen and the same antigen in the patient’s serum for antibody binding sites. Also used for radioimmunotherapy.

10. Receptor binding - this class of radiopharmaceuticals is characterized by their high affinity to bind to
specific receptor sites.

11. Physiochemical adsorption - the localization of methylenediphosphonate (MDP) occurs primarily by adsorption in the mineral phase of the bone.


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REFERENCES

1. Bushberg, J. T. (2012). The essential physics of medical imaging. Philadelphia: Wolters Kluwer Health/Lippincott Williams & Wilkins. Find it at Amazon
2. Heggie, J. C., Liddell, N. A., & Maher, K. P. (1997). Applied imaging technology. Melbourne: St. Vincents Hospital.

Ⓒ A. Manickam 2018

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