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ANKYLOSING SPONDYLITIS

Rheumatology

ANKYLOSING SPONDYLITIS

1. Ankylosing means "fusing," while spondylitis means "inflammation of the spine."

2. AS is a systemic disease marked by ascending axial inflammation, which, if left untreated, leads to eventual spinal and SI joint fusion resulting in a radiographic bamboo spine.

3. Age of onset: 20-30 years, affects men more than women.

4. Patients have significant morning stiffuess/pain, which is improved with activity, A/W symptomatic & painful sacroilitis.

5. Extra-articular manifestations: iritis/uveitis (about 1/3 of patients), conjunctivitis, IHD, aortic insufficiency/aortitis, apical pulmonary fibrosis, lgA nephropathy.

6. Iritis or anterior uveitis may precede sacroiliitis and usually presents as unilateral pain, photophobia, and increased lacrimation.


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REFERENCES

1. Wilkinson, I. (2017). Oxford handbook of clinical medicine. Oxford: Oxford University Press.
2. Hannaman, R. A., Bullock, L., Hatchell, C. A., & Yoffe, M. (2016). Internal medicine review core curriculum, 2017-2018. CO Springs, CO: MedStudy.
3. Image: no reference available.

Ⓒ A. Manickam 2018

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