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RHEUMATOID ARTHRITIS-BIOLOGIC AGENTS

Rheumatology

RHEUMATOID ARTHRITIS-BIOLOGIC AGENTS

1. Biologics are made with animal, microbial, or human proteins, in contrast to DMARDs, which are made from chemicals.

2. They can be broken down into those that inhibit tumor necrosis factor (anti-TNFs) or those that inactivate other factors.

3. Infliximab, adalimumab, certolizumab, and golimumab are monoclonal antibodies that bind and inactivate TNF.

4. For RA, these agents are most beneficial when combined with MTX and have been shown to halt and heal erosive damage!

5. A/W drug-induced lupus & other SE: injection site/infusion reactions, infections, increased risk for skin cancer, cytopenias, CNS demyelination, and worsening heart failure.

6. Not recommended for patients with NYHA class III/IV heart failure as they may worsen CHF.


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REFERENCES

1. Wilkinson, I. (2017). Oxford handbook of clinical medicine. Oxford: Oxford University Press.
2. Hannaman, R. A., Bullock, L., Hatchell, C. A., & Yoffe, M. (2016). Internal medicine review core curriculum, 2017-2018. CO Springs, CO: MedStudy.
3. Image: no reference available.

Ⓒ A. Manickam 2018

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