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PRIMARY HEMOSTASIS DISORDERS-THROMBOCYTOPENIA

Rheumatology

PRIMARY HEMOSTASIS DISORDERS-THROMBOCYTOPENIA

1. Impaired production: due to bone marrow failure from toxins (including alcohol), infiltration, aplasia, sepsis, and HIV infection. Often there is concomitant anemia and/or leukopenia.

2. Hypersplenism: thrombocytopenia is usually modest and accompanied by a reduction in the other cell lines (leukopenia and anemia).

3. Consumptive process: such as DIC, HIT (heparin-induced thrombocytopenia), TTP/HUS, and HELLP.

4. Immune thrombocytopenia (ITP): either idiopathic or drug-induced.


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REFERENCES

1. Wilkinson, I. (2017). Oxford handbook of clinical medicine. Oxford: Oxford University Press.
2. Hannaman, R. A., Bullock, L., Hatchell, C. A., & Yoffe, M. (2016). Internal medicine review core curriculum, 2017-2018. CO Springs, CO: MedStudy.
3. Image: no reference available.

Ⓒ A. Manickam 2018

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