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MHC-HUMAN LEUKOCYTE ANTIGENS (HLA)

Rheumatology

MHC-HUMAN LEUKOCYTE ANTIGENS (HLA)

1. Class I includes the HLA-A, HLA-8, and HLA-C antigens, which interact with CD8 or T suppressor cells.

2. Class II includes the HLA-D antigens; e.g., DR2, DR3, and DR4, which interact with CD4 or T helper cells.

3. Note: An easy way to remember this relationship is that both form a product of 8. MHC-1 * CD8 = 8, while MHC-2 * CD4= 8.


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REFERENCES

1. Wilkinson, I. (2017). Oxford handbook of clinical medicine. Oxford: Oxford University Press.
2. Hannaman, R. A., Bullock, L., Hatchell, C. A., & Yoffe, M. (2016). Internal medicine review core curriculum, 2017-2018. CO Springs, CO: MedStudy.
3. Image: no reference available.

Ⓒ A. Manickam 2018

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