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MHC-HLA B27

Rheumatology

MHC-HLA B27

1. Reactive arthritis: 60-80%, higher when sacroiliitis is present.
2. Ankylosing spondylitis (AS): 90%.
3. Psoriatic arthritis: up to 60% (particularly with spinal/axial disease).
4. Inflammatory bowel disease (IBD) with associated axial joint arthritis: up to 60%.

NOTE: this test has limited clinical usefulness if not ordered in the right clinical scenario. A negative HLA-B27 test is useful in ruling out ankylosing spondylitis.


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REFERENCES

1. Wilkinson, I. (2017). Oxford handbook of clinical medicine. Oxford: Oxford University Press.
2. Hannaman, R. A., Bullock, L., Hatchell, C. A., & Yoffe, M. (2016). Internal medicine review core curriculum, 2017-2018. CO Springs, CO: MedStudy.
3. Image: no reference available.

Ⓒ A. Manickam 2018

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