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DRUG INDUCED LUPUS

Rheumatology

DRUG INDUCED LUPUS

1. Classic drug-induced lupus (OIL) can be caused by procainamide, hydralazine, chlorpromazine, propylthiouracil, phenytoin, and TNF inhibitors.

2. Patients develop constitutional symptoms (fever, arthralgias), serositis, rash while taking any of the above drugs.

3. ANA & and anti-histone antibody are positive. C3 and C4 usually are normal, anti-dsDNA is rarely positive, and there commonly is no kidney or CNS involvement.

4. Treatment: Symptoms usually resolve within 4-8 weeks after stopping the offending agent. NSAIDs and anti-malarials can be used.


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REFERENCES

1. Wilkinson, I. (2017). Oxford handbook of clinical medicine. Oxford: Oxford University Press.
2. Hannaman, R. A., Bullock, L., Hatchell, C. A., & Yoffe, M. (2016). Internal medicine review core curriculum, 2017-2018. CO Springs, CO: MedStudy.
3. Image: no reference available.

Ⓒ A. Manickam 2018

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