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ANTIBODIES-SPECIFIC ANTINUCLEAR ANTIBODIES

Rheumatology

ANTIBODIES-SPECIFIC ANTINUCLEAR ANTIBODIES

1. Anti-dsDNA (in high titer), anti-ribosomal P protein and anti-Smith (anti-Sm) are very specific for SLE.

2. Anti-U1-RNP: absence of the antibody excludes MCTD.

3. Antihistone: very sensitive (> 95%) for drug-induced lupus, absence effectively rules out DIL.

4. Anti-Scl-70 is specific for progressive systemic sclerosis.


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REFERENCES

1. Wilkinson, I. (2017). Oxford handbook of clinical medicine. Oxford: Oxford University Press.
2. Hannaman, R. A., Bullock, L., Hatchell, C. A., & Yoffe, M. (2016). Internal medicine review core curriculum, 2017-2018. CO Springs, CO: MedStudy.
3. Image: no reference available.

Ⓒ A. Manickam 2018

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