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1. Vasculitis is the inflammation of blood vessel walls that can lead to narrowing, obstruction, ischemia, or aneurysm formation.

2. Vasculitis is classified by the size of blood vessel affected and the presence of anti-neutrophil cytoplasmic antibodies (ANCAs).

3. Most common ANCA-positive vasculitis: Wegner's granulomatosis, microscopic polyangitis, Churg-Strauss syndrome.

4. Caused by either immune complex deposition or complement activation.

5. Frequently P/W include myalgias/arthralgias, neuropathy, fever, malaise, and weight loss. Consider vasculitis in a patient with palpable purpura or mononeuritis multiplex!

6. ESR & CRP may be elevated. Diagnosis is confirmed with biopsies or angiograms.


1. Wilkinson, I. (2017). Oxford handbook of clinical medicine. Oxford: Oxford University Press.
2. Hannaman, R. A., Bullock, L., Hatchell, C. A., & Yoffe, M. (2016). Internal medicine review core curriculum, 2017-2018. CO Springs, CO: MedStudy.
3. Image: no reference available.

Ⓒ A. Manickam 2018

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