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ANTIBODIES-ANCA

Rheumatology

ANTIBODIES-ANCA

1. Autoimmune antibodies against antigens in the cytoplasm of neutrophils, markers for vasculitis.

2. The combination of c-ANCA+ and anti-PR3+ is very specific for granulomatosis with polyangiitis (GPA; Wegener granulomatosis).

3. c-ANCA+ plus anti-PR3+: think GPA.

4. p-ANCA+ plus anti-MPO+: Think MPA, EGPA, Churg-Strauss, pauci-immune RPGN, Anti-GBM, and drug-induced.


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REFERENCES

1. Wilkinson, I. (2017). Oxford handbook of clinical medicine. Oxford: Oxford University Press.
2. Hannaman, R. A., Bullock, L., Hatchell, C. A., & Yoffe, M. (2016). Internal medicine review core curriculum, 2017-2018. CO Springs, CO: MedStudy.
3. Image: no reference available.

Ⓒ A. Manickam 2018

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