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SJOGREN SYNDROME

Rheumatology

SJOGREN SYNDROME

1. Sjogren syndrome is caused by a CD4+ T-cell lymphocytic infiltrate that destroys the exocrine glands (lacrimal and salivary glands), resulting in decreased secretions from these glands.

2. Primary disease - not A/W rheumatologic disease. P/W sicca complex (dry eyes & mouth with parotitis).

3. Secondary disease - A/W RA, SLE, polymyositis, and systemic sclerosis.

4. Assess history for xerostomia and xerophthalmia; check for autoantibodies; and biopsy of minor salivary glands to confirm Dx.

5. Complications: > 40-fold increased risk of B-cell lymphoma, dental caries, xerostomia (dry mouth), xerophthalmia (dry eyes).

6. Symptomatic management.


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REFERENCES

1. Wilkinson, I. (2017). Oxford handbook of clinical medicine. Oxford: Oxford University Press.
2. Hannaman, R. A., Bullock, L., Hatchell, C. A., & Yoffe, M. (2016). Internal medicine review core curriculum, 2017-2018. CO Springs, CO: MedStudy.
3. Image: no reference available.

Ⓒ A. Manickam 2018

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