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RHEUMATOID FACTOR AND ANTI-CCP

Rheumatology

RHEUMATOID FACTOR AND ANTI-CCP

1. Rheumatoid factor (RF) is an auto-antibody that binds to the Fc region of IgG, positive in 80-85% of patients with RA.

2. Sensitive but not specific as it is present in other diseases: chronic lung disease, chronic infections (TB, HIV, viral hepatitis), Sjogren's, SLE, infectious endocarditis, and hematologic malignancies.

3. The anti-citrullinated cyclic peptide (anti-CCP antibody), is highly specific for RA (97%) and tends to portend a poorer prognosis.

4. The presence of both RF and anti-CCP antibodies is associated with more aggressive RA.


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REFERENCES

1. Wilkinson, I. (2017). Oxford handbook of clinical medicine. Oxford: Oxford University Press.
2. Hannaman, R. A., Bullock, L., Hatchell, C. A., & Yoffe, M. (2016). Internal medicine review core curriculum, 2017-2018. CO Springs, CO: MedStudy.
3. Image: no reference available.

Ⓒ A. Manickam 2018

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