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RHEUMATOID ARTHRITIS-JOINTS & RADIOLOGY

Rheumatology

RHEUMATOID ARTHRITIS-JOINTS & RADIOLOGY

1. The knee is the most common single joint initially involved in RA; but, over time, small joints-in a symmetric fashion-are more commonly involved.

2. In fact, the forefoot has proven to be the site of earliest radiographic changes in RA, and the head of the 5th metatarsal bone may be the location of the earliest erosion.

3. Erosion of the ulnar styloid process is most specific for RA, leading to ulnar deviation.

4. C-spine: Patients with chronic, severe disease may develop cervical instability at the atlanto-axial articulation (Cl-C2). The rest of the axial skeleton is spared.

5. Pathology: inflamed membrane of granulation tissue (pannus) stimulates the release of cytokines, leading to cartilage destruction, bone erosion, and an inflammatory synovial fluid.


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REFERENCES

1. Wilkinson, I. (2017). Oxford handbook of clinical medicine. Oxford: Oxford University Press.
2. Hannaman, R. A., Bullock, L., Hatchell, C. A., & Yoffe, M. (2016). Internal medicine review core curriculum, 2017-2018. CO Springs, CO: MedStudy.
3. Image: no reference available.

Ⓒ A. Manickam 2018

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