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WEGNER'S GRANULOMATOSIS-INVESTIGATION

Respiratory

WEGNER'S GRANULOMATOSIS-INVESTIGATION

1. The ANCA test (anti-neutrophil cytoplasmic antibody thought to be a destructive auto-antibody) is often used as an adjunctive test - 90% sensitive and 90% specific.

2. When positive in a patient with GPA, it is virtually always c-ANCA (96%).

3. The additional important positive antibody is anti-PR3.

4. Confirm diagnosis from either a biopsy of the nasal membrane or a lung biopsy.

5. A kidney biopsy is not diagnostic because it may not show the granulomas, is much more invasive, and doesn't allow for differentiation between forms of vasculitis.


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REFERENCES

1. Wilkinson, I. (2017). Oxford handbook of clinical medicine. Oxford: Oxford University Press.
2. Hannaman, R. A., Bullock, L., Hatchell, C. A., & Yoffe, M. (2016). Internal medicine review core curriculum, 2017-2018. CO Springs, CO: MedStudy.
3. Image: no reference available.

Ⓒ A. Manickam 2018

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