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STROKE-ANTICOAGULANT THERAPY

Neurology

STROKE-ANTICOAGULANT THERAPY

1. Immediate anticoagulant therapy in patients with acute ischemic stroke is not associated with any significant net short- or long-term benefit.

2. Best reason to anticoagulate from cardiac sources of emboli, from non-valvular AF & mural thrombus from MI (Ryder & Benjamin, 1999).

3. Among patients with non-valvular AF, anticoagulation can reduce stroke by 60% (Hart et al., 2007).

4. Agents used: Warfarin (inhibits Vit K-dependent coagulation factors, for valvular & non-valvular AF); Dabigatran (direct thrombin inhibitor, for non-valvular AF); Rivaroxaban (factor Xa inhibitor, for non-valvular AF); Apixaban (factor Xa inhibitor, for non-valvular AF).


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REFERENCES

1. Wilkinson, I. (2017). Oxford handbook of clinical medicine. Oxford: Oxford University Press.
2. Hannaman, R. A., Bullock, L., Hatchell, C. A., & Yoffe, M. (2016). Internal medicine review core curriculum, 2017-2018. CO Springs, CO: MedStudy.
3. Image: no reference available.

Ⓒ A. Manickam 2018

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