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SPASTICITY-CLONIDINE & TIZANIDINE

Neurology

SPASTICITY-CLONIDINE & TIZANIDINE

1. Centrally acting alpha 2 -adrenergic agonists that act negatively on the pontine locus cereleus (produces norepinephrine in response to stressful stimuli) resulting in pre-synaptic inhibitory modulation of spinal reflexes.

2. Used in SCI, TBI and MS.

3. Adverse effects: hypotension, sedation, bradykinesia, dry mouth, dizziness.

4. Withdrawal after long-term use may lead to severe hypertensive crisis, may impair hypoglycemia-induced tachycardia.


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REFERENCES

1. Wilkinson, I. (2017). Oxford handbook of clinical medicine. Oxford: Oxford University Press.
2. Hannaman, R. A., Bullock, L., Hatchell, C. A., & Yoffe, M. (2016). Internal medicine review core curriculum, 2017-2018. CO Springs, CO: MedStudy.
3. Image: no reference available.

Ⓒ A. Manickam 2018

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