Home
Radiology Guides Anatomy Physio & Path Medicine Physics Contact
SPASTICITY-BOTULINUM TOXIN

Neurology

SPASTICITY-BOTULINUM TOXIN

1. All 7 serotypes affect the NMJ, blocking NM transmission by inhibiting the pre-synaptic release of ACh.
2. Onset of action: 4-10 days.
3. Length of effect: 3-6 months (3 days initial effect, 3 weeks peak effect, 3 months duration).
4. Optimal injection is guided by nerve stimulator or by seeking the motor end-plate using an EMG.
5. Precise injection into the motor end-plate has been shown to optimize the resulting paralysis.
6. Precise injection leads to maximal muscle paralysis per unit of toxin used.


Avatar
REFERENCES

1. Wilkinson, I. (2017). Oxford handbook of clinical medicine. Oxford: Oxford University Press.
2. Hannaman, R. A., Bullock, L., Hatchell, C. A., & Yoffe, M. (2016). Internal medicine review core curriculum, 2017-2018. CO Springs, CO: MedStudy.
3. Image: no reference available.

Ⓒ A. Manickam 2018

+ Home