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PARKINSONS & PARKINSONISM-PATHOLOGY

Neurology

PARKINSONS & PARKINSONISM-PATHOLOGY

1. The pathologic findings are loss of pigmented cells in the substantia nigra and other pigmented nuclei (locus ceruleus, raphe, and dorsal motor nucleus of the vagus).

2. Many of the remaining cells contain eosinophilic cytoplasmic inclusions, surrounded by a faint halo, called Lewy bodies.

3. The motor features of Parkinson disease are caused by the dropout of dopamine-producing cells in the substantia nigra.

4. 80% of patients with PD will eventually develop a dementia of the Lewy body type.


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REFERENCES

1. Wilkinson, I. (2017). Oxford handbook of clinical medicine. Oxford: Oxford University Press.
2. Hannaman, R. A., Bullock, L., Hatchell, C. A., & Yoffe, M. (2016). Internal medicine review core curriculum, 2017-2018. CO Springs, CO: MedStudy.
3. Image: no reference available.

Ⓒ A. Manickam 2018

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