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MULTIPLE SCLEROSIS-MANAGEMENT

Neurology

MULTIPLE SCLEROSIS-MANAGEMENT

1. The treatment of acute exacerbations is high-dose corticosteroids.

2. Glucocorticoids may shorten the duration of exacerbations but do not alter the natural history of MS - IV methylprednisolone, 1g/day for 3-7 days, followed by a rapid prednisone taper.

3. 2012 Cochrane review showed no dif­ference in outcomes when comparing oral vs. IV steroids for relapses.

4. Parenteral corticosteroids are the treatment for optic neuritis.

5. Interferon and glatiramer (Copaxone®, a synthetic amino acid polymer) reduce relapses by 30%, while natalizumab reduces relapses by 60%.


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REFERENCES

1. Wilkinson, I. (2017). Oxford handbook of clinical medicine. Oxford: Oxford University Press.
2. Hannaman, R. A., Bullock, L., Hatchell, C. A., & Yoffe, M. (2016). Internal medicine review core curriculum, 2017-2018. CO Springs, CO: MedStudy.
3. Image: no reference available.

Ⓒ A. Manickam 2018

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