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MILD TO MODERATE PARKINSONS Tx: MAO-B INHIBITOR

Neurology

MILD TO MODERATE PARKINSONS Tx: MAO-B INHIBITOR

1. MAO-B inhibitor selegiline delays the need for L-dopa in patients with mild PD by 9 months.

2. Some evidence that rasagiline may also slow decompensation in early Parkinson disease.

3. No treatment for PD has been proven to be "neuroprotective."

4. Combining selegiline with tricyclics or SSRIs can potentially cause the serotonin syndrome.


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REFERENCES

1. Wilkinson, I. (2017). Oxford handbook of clinical medicine. Oxford: Oxford University Press.
2. Hannaman, R. A., Bullock, L., Hatchell, C. A., & Yoffe, M. (2016). Internal medicine review core curriculum, 2017-2018. CO Springs, CO: MedStudy.
3. Image: no reference available.

Ⓒ A. Manickam 2018

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