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AMYOTROPHIC LATERAL SCLEROSIS

Neurology

AMYOTROPHIC LATERAL SCLEROSIS

1. The hallmark of ALS is marked, simultaneous UMN & LMN signs. Men are affected more often than women.

2. P/W diffuse hyperreflexia and spasticity (UMN) + fasciculations, weakness, and atrophy (LMN).

3. Consider ALS in a patient with profound LMN signs in the LL & intact cognition.

4. ALS is relentlessly progressive, involving upper and lower extremities, truncal and bulbar musculature, and is terminal typically within 3-5 years after diagnosis.

5. Riluzole is commonly used, but extends life by only about 3 months.

6. DD - post-polio syndrome.


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REFERENCES

1. Wilkinson, I. (2017). Oxford handbook of clinical medicine. Oxford: Oxford University Press.
2. Hannaman, R. A., Bullock, L., Hatchell, C. A., & Yoffe, M. (2016). Internal medicine review core curriculum, 2017-2018. CO Springs, CO: MedStudy.
3. Image: no reference available.

Ⓒ A. Manickam 2018

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