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GUILLAIN-BARRE SYNDROME (GBS)-MANAGEMENT

Neurology

GUILLAIN-BARRE SYNDROME (GBS)-MANAGEMENT

1. Measurement of vital capacity (VC), maximal inspiratory pressure (MIP), and maximal expiratory pressure (MEP) are used for the bedside estimation of diaphragmatic strength and to predict respiratory failure.

2. Use the 20-30-40 rule to determine need for ventilator support. VC < 20 mL/kg, MIP less negative than -30 cmH 2 O, and MEP < 40 cmH 2 O.

3. Plasmapheresis and IV immunoglobulin therapy (IVIG) are equally effective. Use if patients present within 4 weeks of onset.

4. Complete recovery is the norm for about 80%; however, 10% of patients have a very prolonged course with or without significant residual weakness. Approximately 5% of patients do not survive the illness.


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REFERENCES

1. Wilkinson, I. (2017). Oxford handbook of clinical medicine. Oxford: Oxford University Press.
2. Hannaman, R. A., Bullock, L., Hatchell, C. A., & Yoffe, M. (2016). Internal medicine review core curriculum, 2017-2018. CO Springs, CO: MedStudy.
3. Image: no reference available.

Ⓒ A. Manickam 2018

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