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ACUTE KIDNEY INJURY (AKI)-NSAIDs

Nephrology

ACUTE KIDNEY INJURY (AKI)-NSAIDs

1. Pre-renal failure - by inhibiting prostaglandin production, leading to decreased glomerular perfussion pressure.

2. Hyperkalemia - due to inhibition of renin release from JG apparatus, leading to low aldosterone, due to reduced K + excreation.

3. NSAIDs also can cause an acute or a chronic interstitial nephritis, with nephrotic-range proteinuria (common) and papillary necrosis (rare).


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REFERENCES

1. Wilkinson, I. (2017). Oxford handbook of clinical medicine. Oxford: Oxford University Press.
2. Hannaman, R. A., Bullock, L., Hatchell, C. A., & Yoffe, M. (2016). Internal medicine review core curriculum, 2017-2018. CO Springs, CO: MedStudy.
3. Image: no reference available.

Ⓒ A. Manickam 2018

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