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OSMOLAL GAP

Nephrology

OSMOLAL GAP

1. The osmolality of the blood is determined mainly by concentrations of Na+, glucose, and urea.

2. The osmolal gap (OG) helps you determine whether unmeasured osmotically active substances (osmoles) are circulating in the blood (and possibly causing an acidosis).

3. High OG, ingestion of substances: methanol, ethylene glycol ingestions and propylene glycol.

4. High OG, other causes: CKD, ketoacidosis, lactic acidosis.


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REFERENCES

1. Wilkinson, I. (2017). Oxford handbook of clinical medicine. Oxford: Oxford University Press.
2. Hannaman, R. A., Bullock, L., Hatchell, C. A., & Yoffe, M. (2016). Internal medicine review core curriculum, 2017-2018. CO Springs, CO: MedStudy.
3. Image: no reference available.

Ⓒ A. Manickam 2018

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