Home
Radiology Guides Anatomy Physio & Path Medicine Physics Contact
LATE DISTAL TUBULE

Nephrology

LATE DISTAL TUBULE

1. The late distal tubule and cortical collecting duct act the same, allowing for further solute and water reab­sorption - regulated by aldosterone and ADH.

2. There are 2 important cell types in the late distal tubule and cortical collecting duct that reabsorb solutes.

3. Principal cells: ATPase counter-transport Na + (into interstitium) and K + (into filtrate); stimulated by aldosterone and hyper­kalemia and inhibited by potassium-sparing diuretics.

4. Intercalated cells: secrete H + (into filtrate) via an ATPase active transport pump; for every H + secreted, one HCO 3 - is reab­sorbed via the action of carbonic anhydrase.


Avatar
REFERENCES

1. Wilkinson, I. (2017). Oxford handbook of clinical medicine. Oxford: Oxford University Press.
2. Hannaman, R. A., Bullock, L., Hatchell, C. A., & Yoffe, M. (2016). Internal medicine review core curriculum, 2017-2018. CO Springs, CO: MedStudy.
3. Image: no reference available.

Ⓒ A. Manickam 2018

+ Home