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DRUGS & ATN

Nephrology

DRUGS & ATN

1. Amphotericin B causes ATN at a cumulative dose at > 3 gm,  causing Type 1 & 2 RTA.

2. Aminoglycosides (AG) cause proximal tubule damage, GFR begins to fall 5-7 days after the start. OD dosing is less nephrotoxic than multi-daily doses. Gentamicin is the most toxic AG.

3. Cisplatin causes a magnesiuria and hypomagnesemia.


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REFERENCES

1. Wilkinson, I. (2017). Oxford handbook of clinical medicine. Oxford: Oxford University Press.
2. Hannaman, R. A., Bullock, L., Hatchell, C. A., & Yoffe, M. (2016). Internal medicine review core curriculum, 2017-2018. CO Springs, CO: MedStudy.
3. Image: no reference available.

Ⓒ A. Manickam 2018

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