Home
Radiology Guides Anatomy Physio & Path Medicine Physics Contact
DIURETIC-THIAZIDE DIURETICS

Nephrology

DIURETIC-THIAZIDE DIURETICS

1. Thiazide diuretics have to be secreted into the filtrate to be effective and, hence, are less effec­tive in patients with extremely low GFR.

2. Inhibit the Na/CI co-transporter in the early distal tubule.

3. Increase deliv­ery of Na+ to the early distal tubule and up-regulation of the counter-transport of the Na/K ATPase, leading to hypokalemia.

4. Thiazides actually increase calcium reabsorption, which is in contrast with the action of loop diuretics - avoid in primary hyperparathyroidism or hypercalcemia of malignancy.

5. Thiazides can be useful in reducing urinary calcium in patients with kidney stones.


Avatar
REFERENCES

1. Wilkinson, I. (2017). Oxford handbook of clinical medicine. Oxford: Oxford University Press.
2. Hannaman, R. A., Bullock, L., Hatchell, C. A., & Yoffe, M. (2016). Internal medicine review core curriculum, 2017-2018. CO Springs, CO: MedStudy.
3. Image: no reference available.

Ⓒ A. Manickam 2018

+ Home