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DIURETIC-CARBONIC ANHYDRASE INHIBITORS

Nephrology

DIURETIC-CARBONIC ANHYDRASE INHIBITORS

1. Carbonic anhydrase inhibitors (acetazolamide) disrupt the proximal tubule Na + /H + counter-transporter by reducing the availabilities of H + in the tubule cells and H 2 CO 3 - in the lumen.

2. Then, the Na + /H + counter-transporter does not have substrate. Na + is not absorbed and H + is not secreted.

3. A mild diuresis ensues (as well as generation of a metabolic acidosis, similar to proximal, Type 2 RTA).


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REFERENCES

1. Wilkinson, I. (2017). Oxford handbook of clinical medicine. Oxford: Oxford University Press.
2. Hannaman, R. A., Bullock, L., Hatchell, C. A., & Yoffe, M. (2016). Internal medicine review core curriculum, 2017-2018. CO Springs, CO: MedStudy.
3. Image: no reference available.

Ⓒ A. Manickam 2018

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