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RAPIDLY PROGRESSIVE GN (RPGN)

Nephrology

RAPIDLY PROGRESSIVE GN (RPGN)

1. GN that progresses rapidly (days to weeks) & is associated glo­merular crescents (extracapillary proliferation) inside Bowman's capsule.

2. Rapidly progressive renal failure with nephritic urine sediment, with high or low complement, with systemic or primary renal disorder.

3. Type 1 (deposition of anti-GBM antibodies), type 2 (immune complex deposition), type 3 (no evidence of immune deposits).

4. Causes: Goodpasture's, lupus, granulomatosis with polyangiitis, & immune complex disease.

5. Treat RPGN empirically with high-dose methylpred­nisolone, then prednisone + cyclophosphamide +/­ plasmapheresis (if pulmonary hemorrhage).

6. Once biopsy results available, institute definitive treatment.


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REFERENCES

1. Wilkinson, I. (2017). Oxford handbook of clinical medicine. Oxford: Oxford University Press.
2. Hannaman, R. A., Bullock, L., Hatchell, C. A., & Yoffe, M. (2016). Internal medicine review core curriculum, 2017-2018. CO Springs, CO: MedStudy.
3. Image: no reference available.

Ⓒ A. Manickam 2018

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