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ALDOSTERONE, ALKALEMIA & POTASSIUM

Nephrology

ALDOSTERONE, ALKALEMIA & POTASSIUM

1. Aldosterone enhances distal sodium reabsorption by activating distal tubular Na + /H + and Na + /K + pumps at the expense of H + loss (alkalosis) and K + loss (hypokalemia).

2. This can result in "paradoxical aciduria," a low urine pH in the setting of metabolic alkalosis.

3. In alkalemia, K + shifts from the extracellular space to the intracellular space in exchange for H + , exacerbating hypokalemia.


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REFERENCES

1. Wilkinson, I. (2017). Oxford handbook of clinical medicine. Oxford: Oxford University Press.
2. Hannaman, R. A., Bullock, L., Hatchell, C. A., & Yoffe, M. (2016). Internal medicine review core curriculum, 2017-2018. CO Springs, CO: MedStudy.
3. Image: no reference available.

Ⓒ A. Manickam 2018

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