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HEMOSTASIS-SECONDARY HEMOSTASIS (COAGULATION CASCADE)

Haematology

HEMOSTASIS-SECONDARY HEMOSTASIS (COAGULATION CASCADE)

1. All coagulation is initiated by tissue factor (released at the site of injury) interacting with Factor VII.

2. The intrinsic pathway factors (VIII, IX, and XI) serve solely to amplify this formation of thrombin-and can do so only after a small amount of thrombin is formed by the extrinsic pathway.

3. Thrombin is the key. A little bit of thrombin immediately starts building more thrombin while it builds the thrombus.

4. Thrombin converts fibrinogen to fibrin, activates factors VIII, XII & XIII.


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REFERENCES

1. Wilkinson, I. (2017). Oxford handbook of clinical medicine. Oxford: Oxford University Press.
2. Hannaman, R. A., Bullock, L., Hatchell, C. A., & Yoffe, M. (2016). Internal medicine review core curriculum, 2017-2018. CO Springs, CO: MedStudy.
3. Image: no reference available.

Ⓒ A. Manickam 2018

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