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NOAC-PHARMACOLOGY

Haematology

NOAC-PHARMACOLOGY

1. Two categories - direct thrombin inhibitors & the factor Xa inhibitors.

2. Direct thrombin inhibitors - inhibitors inactivate soluble and fibrin-bound thrombin and limit thrombogenesis and thrombus growth (Dabigatran).

3. Factor Xa inhibitors - directly inhibit the enzyme responsible for thrombin formation (Apixaban & Rivaroxaban).


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REFERENCES

1. Wilkinson, I. (2017). Oxford handbook of clinical medicine. Oxford: Oxford University Press.
2. Hannaman, R. A., Bullock, L., Hatchell, C. A., & Yoffe, M. (2016). Internal medicine review core curriculum, 2017-2018. CO Springs, CO: MedStudy.
3. Image: no reference available.

Ⓒ A. Manickam 2018

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