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NOAC-MANAGEMENT OF BLEEDING

Haematology

NOAC-MANAGEMENT OF BLEEDING

1. Minor bleeding may be managed with local measures and temporary drug cessation.

2. Prohaemostatic agents may be used but have no proven efficacy.

3. Dabigatran may be removed with dialysis but factor Xa inhibitors are too highly protein-bound.

4. Vitamin K does not reduce the anticoagulant activity of NOACs and is of no benefit.

5. Reversal agents have now been developed for NOACs but they are just entering clinical trial evaluation. Management of bleeding often
requires expert haematological advice.


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REFERENCES

1. Wilkinson, I. (2017). Oxford handbook of clinical medicine. Oxford: Oxford University Press.
2. Hannaman, R. A., Bullock, L., Hatchell, C. A., & Yoffe, M. (2016). Internal medicine review core curriculum, 2017-2018. CO Springs, CO: MedStudy.
3. Image: no reference available.

Ⓒ A. Manickam 2018

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