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COLON CANCER-PATHOLOGY

Gastroenterology

COLON CANCER-PATHOLOGY

1. Most GI cancers arise from adenomas.

2. 25% of colorectal cancers are located distal to the splenic flexure.

3. Adenomas with high-grade features (high-grade dysplasia, presence of villous histology, size > 10cm) progress to cancer in 5-10 years.

4. Large or villous adenomatous polyps are likely to harbor or progress to cancer.

5. Hyperplastic polyps have no malignant potential and contain no features of dysplasia. Hyperplasia, by definition, is increased growth of normal tissue.


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REFERENCES

1. Wilkinson, I. (2017). Oxford handbook of clinical medicine. Oxford: Oxford University Press.
2. Hannaman, R. A., Bullock, L., Hatchell, C. A., & Yoffe, M. (2016). Internal medicine review core curriculum, 2017-2018. CO Springs, CO: MedStudy.
3. Image: no reference available.

Ⓒ A. Manickam 2018

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