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POSTERIOR PITUITARY

Endocrinology

POSTERIOR PITUITARY

1. The hypothalamus controls the anterior pituitary hormonally, posterior pituitary (neurohypophysis) via direct stimulation.
2. Stores - oxytocin + ADH.
3. ADH secretion is controlled by osmoreceptors in the anterior pituitary.
4. Above a certain osmolality threshold, the kidneys respond proportionately to ADH secretion by concentrating urine.
5. The threshold is increased in chornic hypervolemia + HTN (hence more water is lost); decreased in pregnancy + PMS.
6. Volume contraction => increased ADH secretion + decreased renal reponse threshold.
7. Osmolality = 2[Na] + (Glucose/18) + (BUN/2.8).
8. Thirst begins when serum osm > 295mOsm/L.


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REFERENCES

1. Wilkinson, I. (2017). Oxford handbook of clinical medicine. Oxford: Oxford University Press.
2. Hannaman, R. A., Bullock, L., Hatchell, C. A., & Yoffe, M. (2016). Internal medicine review core curriculum, 2017-2018. CO Springs, CO: MedStudy.
3. Image: no reference available.

Ⓒ A. Manickam 2018

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