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DIABETES MELLITUS-SECRETAGOGUES

Endocrinology

DIABETES MELLITUS-SECRETAGOGUES

1. The sulfonylureas and meglitinides increase insulin secretion.

2. Glipizide is a 2 nd generation sulfonylurea.

3. Weight gain is a common side effect of sulfonylureas.

4. The half-life of these drugs is long, and hypoglycemia can persist in states of overdose or renal impairment.

5. Meglitinides: These drugs are rapid-acting with a very short half-life (repaglinide, nateglinide). Major effect is on postprandial glucose.


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REFERENCES

1. Wilkinson, I. (2017). Oxford handbook of clinical medicine. Oxford: Oxford University Press.
2. Hannaman, R. A., Bullock, L., Hatchell, C. A., & Yoffe, M. (2016). Internal medicine review core curriculum, 2017-2018. CO Springs, CO: MedStudy.
3. Image: no reference available.

Ⓒ A. Manickam 2018

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