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DIABETES MELLITUS-NEWER AGENTS

Endocrinology

DIABETES MELLITUS-NEWER AGENTS

1. Amylin analogs - suppresses glucagon & slows stomach emptying.

2. GLP1 agonists - incretin hormones are secreted by the gut & regulate glucose by stimulating insulin release, inhibiting post-prandial glucagon release, slowing nutrient absorption, and accelerating satiety. Add-on drugs.

3. DPP4 inhibitors - decrease the inactivation of incretins. Biggest effect on decreasing post-prandial glucose. Sitagliptin is an example. SE: pancreatitis, URTI, hypoglycemia (less likely). Add-on drugs.

4. SGLT-2 inhibitor - block the co-transport of sodium & glucose in the proximal tubule. These drugs do not cause hypoglycemia, and they lead to modest weight loss. SE: dehydration, AKI, UTI, genital mycotic infections.


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REFERENCES

1. Wilkinson, I. (2017). Oxford handbook of clinical medicine. Oxford: Oxford University Press.
2. Hannaman, R. A., Bullock, L., Hatchell, C. A., & Yoffe, M. (2016). Internal medicine review core curriculum, 2017-2018. CO Springs, CO: MedStudy.
3. Image: no reference available.

Ⓒ A. Manickam 2018

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