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DIABETES MELLITUS-BIGUANIDES

Endocrinology

DIABETES MELLITUS-BIGUANIDES

1. Metformin is the preferred first line drug for T2DM, unless the patient meets a need for immediate insulin.

SIDE EFFECTS
2. Dose-related abdominal pain and diarrhea and propensity for causing lactic acidosis.

3. Contraindicated in renal dysfunction (GFR < 30 cc/min), decompensated CHF, and acute or chronic metabolic acidosis.

4. Contraindicated in contrast procedures or surgery-because both might cause renal failure => lactic acidosis.


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REFERENCES

1. Wilkinson, I. (2017). Oxford handbook of clinical medicine. Oxford: Oxford University Press.
2. Hannaman, R. A., Bullock, L., Hatchell, C. A., & Yoffe, M. (2016). Internal medicine review core curriculum, 2017-2018. CO Springs, CO: MedStudy.
3. Image: no reference available.

Ⓒ A. Manickam 2018

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