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PTH

Endocrinology

PTH

FUNCTION
1. Stimulates osteoclast activity => releases bone calcium stores.
2. Increases renal tubular calcium absorption + phosphate excretion.
3. Increases 1,25-dehydroxycholecalciferol (1,25-(OH) 2 D) production by increasing activity of kidney hydroxylase.

CONTROLLED BY NEGATIVE FEEDBACK
4. High serum calcium => decreased parathyroid PTH production.


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REFERENCES

1. Wilkinson, I. (2017). Oxford handbook of clinical medicine. Oxford: Oxford University Press.
2. Hannaman, R. A., Bullock, L., Hatchell, C. A., & Yoffe, M. (2016). Internal medicine review core curriculum, 2017-2018. CO Springs, CO: MedStudy.
3. Image: no reference available.

Ⓒ A. Manickam 2018

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