Home
Radiology Guides Anatomy Physio & Path Medicine Physics Contact
ANTI-ANGINAL DRUGS

Cardiology

ANTI-ANGINAL DRUGS

1. Beta-blockers, nitrates are the staples of treatment, CCB also help - decrease myocardial O 2 demand, and decrease afterload.

2. Nitrates decrease preload more than afterload and also dilate coronary vessels, can cause severe decompensation in patients with an acute right ventricular MI (hence, avoid). Patients on nitrates get a sympathetic reflex increase in HR.

3. Beta-blockers decrease myocardial O 2 demand by decreasing HR, BP, & contractility. Beta-blockers complement nitrates well because they decrease the reflex tachycardia.

4. Nifedipine and amlodipine decrease angina by coronary artery vasodilation & peripheral vasodilation (decreases workload).

5. Anti-anginal effect of diltiazem and verapamil is due to their negative chronotropic effect. Should be used cautiously in patients with systolic heart failure due to the negative inotropic effects.


Avatar
REFERENCES

1. Wilkinson, I. (2017). Oxford handbook of clinical medicine. Oxford: Oxford University Press.
2. Hannaman, R. A., Bullock, L., Hatchell, C. A., & Yoffe, M. (2016). Internal medicine review core curriculum, 2017-2018. CO Springs, CO: MedStudy.
3. Image: no reference available.

Ⓒ A. Manickam 2018

+ Home